Saturday, March 2, 2013

Herbal Viagra actually contains the real thing

IF IT looks too good to be true, it probably is. Several "herbal remedies" for erectile dysfunction sold online actually contain the active ingredient from Viagra.

Michael Lamb at Arcadia University in Glenside, Pennsylvania, and colleagues purchased 10 popular "natural" uplifting remedies on the internet and tested them for the presence of sildenafil, the active ingredient in Viagra. They found the compound, or a similar synthetic drug, in seven of the 10 products ? cause for concern because it can be dangerous for people with some medical conditions.

Lamb's work was presented last week at the American Academy of Forensic Sciences meeting in Washington DC.

This article appeared in print under the headline "Herbal Viagra gets a synthetic boost"

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Surgeon Simulator 2013 passes through Steam's Greenlight program, shouldn't have passed med school (video)

Surgeon Simulator 2013 passes through Steam's Greenlight program, lets you be a terrible doctor

One of ten new additions to come from Valve's Greenlight community platform, Surgeon Simulator 2013 was crafted in a mere 48 hours at Global Game Jam and puts you in the role of a clumsy surgeon, responsible for a patient who's unlikely to last the night. You should consult the video after the break to get an idea of the level of incompetence here, but let's just say your efforts are measured by Blood Level. You'll get access to scalpels, hammers and bone saws as you perform heart surgery and brain transplants -- in short, it's going to get messy. Other new additions include Anodyne, Distance, Receiver, and Huntsman: The Orphanage and all of 'em can be downloaded from Steam starting today.

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Via: Joystiq

Source: Steam (1), (2)

Source: http://www.engadget.com/2013/02/28/surgeon-simulator-2013-passes-through-steams-greenlight-program/

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Odd molecular hoops dispel 'junk DNA' myth

Nicolle Rager Fuller / NSF

An artist's conception shows an RNA molecule, which may have served as an early form of life on Earth.

By Charles Choi
LiveScience

The human genome can generate molecular hoops similar in makeup to DNA that could potently interfere with genetic activity, researchers say.

These findings reveal there are secrets within the genomes of humans and other animals that scientists are still uncovering, and the old belief that life has useless junk DNA is more false than ever, scientists added.

Discovering more about circular versions of RNA (a molecule similar to DNA that can carry genetic information) could also lead to new ways of fighting diseases such as diabetes, brain tumors and Parkinson's disease, investigators added.

The human genome ? the blueprint for human life ? is made of DNA. From the genome, intermediate molecules known as RNA are created that help manufacture key biomolecules such as proteins, which then carry out cellular processes.

After international teams of researchers completely sequenced the human genome, they found about 95 percent of it unexpectedly did not code for proteins. Since this noncoding DNA initially seemed to have no known biological function, some scientists referred to it as junk DNA. [Unraveling the Human Genome: 6 Molecular Milestones]

However, over time, researchers have discovered this noncoding DNA can serve a wide variety of vital purposes. For instance, noncoding DNA can give rise to snippets of RNA known as micro-RNA that can suppress the so-called messenger RNA that normally helps manufacture proteins. This micro-RNA serves a key role in controlling genetic activity, and scientists are developing therapies based on micro-RNA to dampen harmful, malfunctioning genes.

Now researchers find the genomes of humans and other animals can generate circular RNA, highly stable rings that can sponge up micro-RNA, apparently keeping them from interfering with genetic activity if necessary.

"There seems to be a whole new layer of gene regulation," researcher J?rgen Kjems, a molecular biologist at Aarhus University in Denmark, told LiveScience.

For instance, Kjems and his colleagues found high levels of a circular RNA they dubbed ciRS-7 in the human and mouse brain. This molecule potently suppresses a micro-RNA named miR-7, which is found in everything from worms to humans. They also found a circular RNA known as Sry that is specific to testicles and targets a micro-RNA known as miR-138, suggesting that circular RNA might play a role in sex development.

In addition, when Nikolaus Rajewsky at the Max Delbr?ck Center for Molecular Medicine in Berlin and his colleagues analyzed human, mouse and nematode worm RNA, they detected thousands of circular RNAs. These were often linked with specific tissues or developmental stages.

The micro-RNA miR-7 regulates a number of disease genes, including Parkinson's disease, brain tumors and diabetes. As such, learning more about circular RNAs "may provide a new treatment strategy for these diseases," Kjems said. Regulating the activity of miR-7 could reduce the activity of the genes causing these diseases, he explained.

Altogether, these findings suggest that circular RNAs form a large class of genetic regulators. It remains uncertain whether these molecules work alone or whether they act by combining with other compounds, such as RNA-binding proteins.

The researchers next plan to introduce these circular molecules in animals "to see their effect on disease development, and from there, design drugs towards the diseases," Kjems said.

The scientists detailed their findings in Thursday's issue of the journal Nature.

Follow LiveScience on Twitter @livescience. We're also on Facebook?and Google+.?

Copyright 2013 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://science.nbcnews.com/_news/2013/03/01/17147699-weird-molecular-hoops-dispell-junk-dna-myth?lite

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Friday, March 1, 2013

CSN: Teams turn to college to defend read-option

Maybe it?s here to stay. Maybe it will quickly fade into oblivion, like the Wing T, the Wishbone and the Wildcat.

Either way, there?s no question that as 32 NFL teams prepare for the draft, free agency and the 2013 season, the read option is factoring heavily into everybody?s decision-making.

?That will be the emphasis in everyone's defensive room in the offseason and do a big study,? said new Cards coach Bruce Arians, the former Temple coach and Colts interim head coach. ?One of the things we did, I hired a defensive coordinator from college [new defensive backs coach Nick Rapone] who's dealt with it. He's got some good ideas on it.

?I think everyone is going to be going to the colleges, rather than the colleges coming to the pros, as far as information on how to handle it.?

Thanks to the success last year of Robert Griffin III of the Redskins, Colin Kaepernick of the 49ers, Russell Wilson of the Seahawks and -- to a lesser extent -- Cam Newton of the Panthers, the read option has become the single hottest topic in the NFL.

With Chip Kelly taking over as head coach of the Eagles, the sustainability of the read option -- an innovative system that asks the quarterback to read the a linebacker or end as he takes the snap and almost immediately decide whether to run, throw or handoff -- will certainly become a huge issue here in Philly.

?Is it sustainable? If you have one [quarterback] and that's what he does and the other guy doesn't do that, and your first guy gets hurt, now you've got to bring in the other guy and change your offense,? said Panthers head coach Ron Rivera, a former Andy Reid assistant with the Eagles. ?That's where you get in trouble.

?If a team's going to commit to it, you're going to see teams have two or three quarterbacks that are the same. If your offense doesn't have any flexibility where it can go from a zone read back to a pro style back to a spread, you can get in trouble. So you've got to be very careful if it's a commitment you're going to make.

?We never really made that type of commitment. We have it as a mixer. We have it just enough that coordinators have to pay attention to what we do. I think off of it we can do so many different things.?

The symbolic arrival of the read option was the 49ers? 45-31 playoff win over the Packers in the conference semifinals. Kaepernick, in only his eighth career start, threw for 263 yards and ran for 181, and the Niners piled up 579 total yards, fourth-highest in NFL postseason history.

So yeah, Packers coach Mike McCarthy is certainly making it a priority to prepare this offseason for the read option.

?Definitely, there?s a lot of conversation about the read option -- rightfully so,? McCarthy said last week at the NFL Scouting Combine in Indianapolis. ?Five hundred seventy nine, that?s a number that will stick in our focus as a defense throughout the offseason.?

McCarthy said he has some college coaches coming to the Packers? facility this spring to work with his assistant coaches, and he?s also sending his defensive coaches to College Station, Texas, to study defending the read option under Texas A&M coach Kevin Sumlin.

?Kevin Sumlin is someone I have great respect for, with his ability to share from both the offensive side and the defensive side his experience in the read option,? McCarthy said. ?It?s something from an education, preparation standpoint that we will grow as a staff and be better prepared for in the future.?

The read option is so unique that even Tim Tebow flourished in it.

Tebow led the Broncos to the playoffs in 2011 and a postseason win over the Steelers, a game in which he threw for 316 yards and two touchdowns and ran for 50 yards and another TD.

Playing in a conventional offense with the Jets, he was a non-entity.

?There?s a lot to be said about it,? said first-year Chargers head coach Mike McCoy, Tebow?s offensive coordinator in Denver. ?It creates a lot of problems for the defense. It?s not something they see every day in practice. The teams that don?t have those type of players, it causes them some issues on Sundays.

?You?ve got to play disciplined football. As we did two years ago, if you get out of place, the guy reads it the wrong way, that?s when you saw Tim make some big runs. Or they overplay Tim, you saw Willis McGahee going for 20 yards inside.

?The way guys are playing it right now it?s going to cause some headaches for a time to come.?

But for how long?

Football, as Marty Mornhinweg used to remind us on a daily basis -- if not an hourly basis -- is cyclical.

Offenses find new ways of scoring points. Defenses adjust. It?s happened throughout history. The only real constants are tackling, blocking and hitting.

?It obviously has been successful,? Steelers general manager Kevin Colbert said. ?Where it will go and how successful it will be, I can?t say.

?Systems come and go, and success of a system will dictate changes defensively. It may fade away, it may not, you can?t really trend where it will stick. All I know is it was successful this year.

?If we have to play a team that utilizes that system, we have to be prepared for it. But you don?t necessarily draft -- at least we won?t -- to play a particular scheme.?

As exciting as the read option can be, Panthers general manager Dave Gettleman points out that most successful teams still run a conventional offense.

Joe Flacco won the Super Bowl. There?s still a place for old-school quarterback play in the NFL.

?Ten of the 12 teams in the playoffs this year had true pocket passers,? Gettleman said. ?I think the read option is an option, exactly what [it?s called]. But at the end of the day, your quarterback has got to make plays from the pocket, and if he can?t you?re going to struggle.?

Cards general manager Steve Keim was one of the few NFL executives who spoke at the Combine who was less than enthusiastic about the read option.

He emphasized that a quarterback still needs to have a quality NFL arm to win football games and said the hits that quarterbacks are likely to take running the pistol or read option make the scheme very dangerous.

We saw it with Robert Griffin III in Washington this year. He put up incredible numbers, but when the playoffs came around, he wasn?t healthy and didn?t last the game.

?At the end of the day you need to be able to spin the football and spin it accurately,? Keim said. ?I think that one of the concerns that comes with that is durability. Those guys are going to take shots, and durability really equals availability.

?And if a player is not going to be available, that's an obvious concern.?

RG3 got hurt, and Kaepernick only started half the season, but Newton hasn?t missed a game in his two-year career, and the Seahawks? Wilson managed to stay healthy all year as a rookie.

?Russell ? would run out of bounds, he would slide, he would do things to keep him out of harm's way,? said Jaguars head coach Gus Bradley, who was the Seahawks? defensive coordinator last year, when Wilson and the read option carried the Seahawks to the playoffs.

?That's the big thing with quarterbacks -- if they're going to keep the ball and run on the perimeter, they're really opening themselves up to some hits and injuries. Franchise quarterbacks are so difficult to find, you really need to protect them.?

And that will likely get harder and harder to do as defensive coaches start devising ways to stop it.

?Without a doubt now defenses are going to start preparing more for it through the offseason program, through training camp,? McCoy said. ?Two years ago we were the first ones really to get into this on a game-by-game basis. Now a lot of teams are doing it. So there?s a lot more time in the offseason to prepare.

??What is our plan? How we going to stop this? What are we going to do?? So really, the advantage changes a little bit to the defense having more time to prepare.?

It?s one more thing for defenses to worry about in an era when practice time has been curtailed, two-a-days have been eliminated and offseason workouts have been reduced.

?We?re doing as much as we can,? Giants coach Tom Coughlin said. ?It?d be foolish not to.?

Source: http://www.csnphilly.com/eagles/nfls-read-option-craze-here-stay

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Adaptxt Keyboard: clean and customizable for just 99 cents

Adaptxt Keyboard

One of the best features of Android is that different portions of the interface can be changed to the user's liking, especially the keyboard. Even with drastic improvements in the stock Android keyboard in the last few iterations, one size certainly doesn't fit all. If you're considering trying out replacement keyboards on your phone or tablet, Adaptxt Keyboard should be on the list for your consideration.

Read on past the break to learn a little more about Adaptxt Keyboard and how it could be the next keyboard you choose to use.

read more



Source: http://feedproxy.google.com/~r/androidcentral/~3/kF6K5fJl9S0/story01.htm

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Video: A Lichtenstein Lie

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Source: http://video.msnbc.msn.com/cnbc/50980086/

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Donna Brazile Doesn't Know Why Her Health Insurance Premium ...

RUSH: Donna Brazile tweeted that her insurance premium went up and she doesn't know why, and I am not kidding.? I literally am not kidding.? Donna Brazile, a tweet, "What's on your menu?? I just got off the phone with my health care provider asking them to explain why my premium jumped up.? No good answer."?

Now, for those of you who do not know who Donna Brazile is (and there may well indeed be many of you who don't), Donna Brazile is a Democrat campaign specialist. She is one of the ranking unelected Democrats in the country. She ran Algore's presidential campaign. She was as close to Bill Clinton as you can get without being Monica Lewinsky. I mean, she is a ranking, powerful Democrat. She is constantly on CNN and other networks doing commentary and strategic analysis for the Democrat Party. She actually tweeted, "Just got off the phone with my health care provider asking them to explain why my premium jumped up. No good answer."

original

Now, a couple of things stand out. First, is it possible...? I'm just asking. Is it possible she's not aware of Obamacare? No, it's not possible. Second, why is she calling her health care provider asking them about her health insurance? She said she called her "health care provider" asking them to explain why her premium jumped up. The "health care provider" is the doctor. What does the doctor have to do with an insurance premium? Now, maybe when she wrote this, by "provider" she means insurance company. I'm sure she does. But stop and think of that!

Here's this high-ranking Democrat who thinks her "health care provider" is her insurance company. I guess, in one way of looking at it, that may be true. But beyond that, somebody said, "Well, maybe she doesn't know about Obamacare." No, no, no, no. She knows everything about Obamacare. The thing that we must ask is: Does she really believe the crap that was said about it? You mean to tell me that Donna Brazile bought the idea that her premium would be reduced $2500 because of Obamacare? You mean to tell me that?

There has to be some explanation for this. It could well be that this is a tweet that's just designed to stir people up like me. Could be she's out there playing a game, knowing full well that people like me are going to do what I'm doing right now in reacting to it. Donna, call your insurance company or whoever provides you your insurance, your CNN employment plan, whatever. I don't know where you get your insurance, but call them. The doctor doesn't have anything to do with your premium. But actually, Donna, what you ought to do is call the White House and ask to speak to the president and ask him why your premium went up, 'cause he's the reason.

There's a piece of legislation out there called Obamacare, and everybody's premiums, costs, are going up. I can't believe it. See, for me, this is the dividing line. Does she really think health care is gonna get cheaper because of Obamacare? That's what these Democrats actually believe? I've thought all along they know they're lying through their teeth to us when they tell us costs are gonna go down. There is one government-provided entitlement that has ever reduced the cost of anything, and that's all this is: A government entitlement program. There isn't one government program that's ever reduced the cost of anything.

Maybe these people are living in their dreamland and actually thought that this was gonna lower their premiums. I'm having a tough time believing that.

Source: http://www.rushlimbaugh.com/daily/2013/02/27/donna_brazile_doesn_t_know_why_her_health_insurance_premium_went_up

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